北京儿童湿疹医院 http://news.39.net/bjzkhbzy/210622/9092307.htmlPaperReading
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DietDiurnallyRegulatesSmallIntestinalMicrobiome-Epithelial-ImmuneHomeostasisandEnteritis
TimurTuganbaev,UriaMor,etal..
Cell,
Dietshapesintestinalphysiology,throughavarietyofmicrobiome-dependentand-independentmechanisms.Throughouta24-hperiod,thesmallintestine(SI)isexposedtodiurnallyvaryingfood-andmicrobiome-derivedantigenicburdensbutmaintainsstrictimmunehomeostasis,whichwhenperturbedingeneticallysusceptibleindividuals,mayleadtoCrohndisease.Inthispaper,theresearchersdemonstratedthatthediurnalregulationofgutimmunitydependsupontheexpressionofMHCIIinducedbyapopulationof
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